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Major Autohemotherapy - MaH
Myalgic encephalomyelitis (ME) is a disease of the nervous, autonomic and the immune system. Its hallmark symptom is post-exertional malaise, a severe worsening of symptoms after cognitive or physical exertion.
Migraine accompanied by severe weakness and total full body pain leaves me bedridden for the duration of a flare.
I have been struggling with this illness for years mostly housebound…always seeking a solution. 🙏🏻
In an Italian Clinical Trial MaH treatments proved effective in treating M.E.
https://www.mdpi.com/2077-0383/11/1/29
Treating ME/CFS is incredibly challenging, so finding a therapy that provides rapid symptom relief is a significant victory. Fortunately, the clinical data suggests that the benefits of oxygen-ozone autohemotherapy (O₂-O₃-AHT) can indeed be sustained long after the initial treatment cycle, rather than just providing a temporary energy boost.
Evidence for Long-Lasting Relief
The most robust data on this comes from a 2021 clinical trial led by the Italian Society of Oxygen Ozone Therapy (SIOOT), which treated 200 ME/CFS patients with O₂-O₃-AHT.
- Significant Amelioration: 77.5% of patients experienced a major reduction in their fatigue levels.
- Total Remission of Symptoms: 43.5% of the patients went from the absolute worst Fatigue Severity Scale score (7) to the best possible score (1).
- Duration of Efficacy: The study tracked patients for a 3-month follow-up, noting "long-lasting fatigue disappearance" with no reported side effects.
Researchers believe this relief lasts because ozone does not act like a temporary chemical stimulant. Instead, it triggers a "mitohormetic" response — a mild, controlled oxidative stress that forces your mitochondria (the cells' energy engines) to repair themselves, while simultaneously reducing the systemic inflammation that drives ME/CFS.
How does ozone therapy actually repair mitochondrial dysfunction and reduce oxidative stress at a cellular level?
Ozone therapy works through a biological concept called mitohormesis—the idea that a mild, temporary stressor forces the body to adapt, repair, and grow stronger.
It seems paradoxical to use ozone (O3)—a highly reactive oxidant—to fix oxidative stress. However, the ozone doesn't act like a destructive free radical during autohemotherapy. Instead, it acts as a chemical alarm bell that wakes up dormant cellular repair mechanisms.
Here is the exact biological cascade that occurs to repair mitochondria and reduce systemic inflammation:
1. The Initial Lipid Reaction
When O mixes with drawn blood, it doesn't actually travel into your cells. It reacts instantly with polyunsaturated fatty acids (PUFAs) and antioxidants in the blood plasma. This brief reaction produces hydrogen peroxide (HOand lipid oxidation products (LOPs). The ozone itself disappears in seconds, but these newly formed LOPs act as vital messenger molecules.
2. Tripping the Nrf2 Master Switch
The LOPs travel through the bloodstream and enter the body's cells, where they interact with a protein complex called Keap1. Normally, Keap1 acts like an anchor, holding down a master regulatory protein called Nrf2 (Nuclear factor erythroid 2-related factor 2). The presence of the LOP messengers causes Keap1 to release Nrf2. Once freed, Nrf2 travels directly into the cell's nucleus and binds to the DNA at the Antioxidant Response Element (ARE).
3. The Endogenous Antioxidant Flood
Binding to the ARE turns on the genetic expression for the body's ultimate "house-made" antioxidants, specifically:
- Superoxide Dismutase (SOD)
- Catalase (CAT)
- Glutathione Peroxidase (GPx)
These internal antioxidants are immensely more powerful than dietary vitamins. They flood the system, aggressively neutralizing the chronic, inflammatory free radicals that drive ME/CFS. This massive reduction in systemic oxidative stress is what finally gives the cells a safe environment to heal.
4. Mitochondrial Resuscitation
Mitochondria (the cell's energy engines) are notoriously fragile; they shut down or become dysfunctional when surrounded by chronic inflammation, leading to profound fatigue. Once the newly minted antioxidants clear the intracellular "smog," the mitochondria can reboot:
- Restored ATP Production: With oxidative stress neutralized, mitochondria resume the efficient production of ATP (adenosine triphosphate), restoring the baseline energy reserves.
- Enhanced Oxygen Delivery: The initial HO
messenger also stimulates red blood cells to produce an enzyme called 2,3-DPG. This enzyme slightly alters hemoglobin, forcing it to release oxygen) much more readily into oxygen-starved tissues and struggling mitochondria.
By forcing this specific pathway to activate, ozone doesn't just act as a temporary stimulant—it fundamentally rebuilds the cell's capacity to protect and power itself.
These treatments are not covered by insurance. Please help…
